Ramirez voiced the titular character of Lammy in the video game Um Jammer Lammy, a spin-off of Pa Rappa the Rapper, on Sony's Play Station console.
She later reprised her role in the latter's sequel for Play Station 2, but had a smaller role.
The series creator and executive producer, Shonda Rhimes explained: "I was looking for a girlfriend for George, but it was in the infancy stages, so I had no idea what I was looking for." Rhimes built the character around Ramirez after she met her.
Ramirez, who was initially given a recurring status at the time of the character's inception, received a star billing in the show's third season, alongside fellow cast member Eric Dane, who portrayed Dr. Ramirez provided a cappella vocals in the song "Silent Night" for the soundtrack of the show's sixth season episode "Holidaze," airing on November 192009.
It could just be like, ‘We hang out and there’s nothing there, and okay, bye.’ I really don’t know. Hahn [Smith] was let go, there still needed to be some sort of continuation of what all that meant for Callie.”DN: Since your character became a lesbian on the show, you have been appearing in PSA’s for the gay-rights group GLAAD, particularly its campaign against California’s Proposition 8. SR: “I am starting a foundation in honor of my best friend, Al D.
Rodríguez \[an actor/singer from Washington Heights who recently died of cancer\]. Perhaps people are rooting for her to find love, and identify with having been through rough times.”DN: There was also some speculation that you’d been offered your own “Grey’s” spinoff.
In addition to her acting career, Ramirez released her first single "Silent Night" in 2009. She was awarded the Ally for Equality Award by the Human Rights Campaign Foundation in 2015. They eventually settled in Tierrasanta, San Diego, California.
Ramirez's interest in music encouraged her mother to send her to San Diego School of Creative and Performing Arts, where she discovered her singing talent during an audition.“And ‘Grey’s’ was my favorite show.” Then, in a twist of fate, ABC execs saw Ramírez’s Tony-winning performance in “Spamalot” and liked her so much they offered her a starring role on the ABC show of her choice. I think I say that because that’s how they brought me into the show, and as an actor, I have a very sensitive and emotional attachment to how I first came on.For Ramírez, it was a no-brainer: “Grey’s Anatomy.” A few months later, Callie Torres was introduced on “Grey’s” as none other than George O’Malley’s love interest. It was like someone yanking me into the television. It was also romantic how George and Callie’s relationship first started.Ramirez is a recipient of a Tony Award, a Screen Actors Guild Award, and a Satellite Award among other accolades.Ramirez's portrayal of the original Lady of the Lake in the 2005 Broadway musical Spamalot, won her acclaim and the Tony Award for Best Featured Actress in a Musical. Callie Torres, in ABC's long-running medical drama Grey's Anatomy.Charles Isherwood of Variety praised her "beautiful, smoky voice", but was critical of her "torchy" performance of “The Man I Love” which ignored, "the wry irony that infuses Ira’s lyrics".